Inhibition of Cytosolic Phospholipase A₂α Impairs an Early Step of Coronavirus Replication in Cell Culture.

ABSTRACT: Coronavirus replication is associated with intracellular membrane rearrangements in infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other membranous structures that are referred to as replicative organelles (ROs). The latter provide a structural scaffold for viral replication/transcription complexes (RTCs) and help to sequester RTC components from recognition by cellular factors involved in antiviral host responses. There is increasing evidence that plus-strand RNA (+RNA) virus replication, including RO formation and virion morphogenesis, affects cellular lipid metabolism and critically depends on enzymes involved in lipid synthesis and processing. Here, we investigated the role of cytosolic phospholipase A₂α (cPLA₂α) in coronavirus r

SUBMITTER: Muller C 

PROVIDER: S-EPMC5790932 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature