Exosomes Mediate Intercellular Transmission of Porcine Reproductive and Respiratory Syndrome Virus.

ABSTRACT: Exosomes are small membrane-enclosed vesicles produced by various cells and actively released into the extracellular space. They participate in intercellular communication and transfer of biologically active proteins, lipids, and nucleic acids. Accumulating evidence suggests that exosomes derived from cells infected by some viruses selectively encapsulate viral proteins, genetic materials, or even virions to mediate cell-to-cell communication and/or virus transmission. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the global swine industry since the late 1980s. Recent studies have shown that major proteins secreted from PRRSV-infected cells are exosomal proteins and that the serum-derived exosomes from PRRSV-infected pigs contain vi

SUBMITTER: Wang T 

PROVIDER: S-EPMC5790938 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature