A non-invasive restraining system for awake mouse imaging.

ABSTRACT:

Background

Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity and function in laboratory animals, such as mice and rats. Most of these studies are performed under anesthesia to avoid movement during the scanning sessions.

Method

Due to the limitations associated with anesthetized imaging, recent efforts have been made to conduct rodent imaging studies in awake animals, habituated to the restraint systems used in these instances. As of now, only one such system is commercially available for mouse scanning (Animal Imaging Research, Boston, MA, USA) integrating the radiofrequency coil electronics with the restraining element, an approach which, although effective in reducing head motion during awake imaging, has some limitations. In the current re

SUBMITTER: Madularu D 

PROVIDER: S-EPMC5790991 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature