Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.

ABSTRACT: The modern immunosuppression regimen has greatly improved short-term allograft outcomes but not long-term allograft survival. Complications associated with immunosuppression, specifically nephrotoxicity and infection risk, significantly affect graft and patient survival. Inducing and understanding pathways underlying clinical tolerance after transplantation are, therefore, necessary. We previously showed full donor chimerism and immunosuppression withdrawal in highly mismatched allograft recipients using a bioengineered stem cell product (FCRx). Here, we evaluated the gene expression and microRNA expression profiles in renal biopsy samples from tolerance-induced FCRx recipients, paired donor organs before implant, and subjects under standard immunosuppression (SIS) without rejection and wi

SUBMITTER: Gallon L 

PROVIDER: S-EPMC5791065 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature