Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate.

ABSTRACT:

Background

The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been attributed to sonic hedgehog (shh) signaling, which originates in the notochord, forms a gradient, and autoinduces shh expression in the floor plate. However, reported data are inconsistent and the spatiotemporal development of the relevant shh expression domains has not been studied in detail. We therefore studied the expression dynamics of shh in rabbit, chicken and Xenopus laevis embryos (as well as indian hedgehog and desert hedgehog as possible alternative functional candidates in the chicken).

Results

Our analysis reveals a markedly divergent pattern within these vert

SUBMITTER: Kremnyov S 

PROVIDER: S-EPMC5791209 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature