Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals.

ABSTRACT:

Background

Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have been conducted in European populations. Here we aimed to identify common genetic variants that affect vitamin D concentrations in individuals of self-reported Arab ethnicity.

Methods

The study included 1151 Arab subjects living in Kuwait. Common variants of single-nucleotide polymorphisms and genes previously associated with vitamin D levels, such as GC, PDE3B, CYP2R1, and NADSYN1, were genotyped. Raw vitamin D level data were corrected for age, body mass index, and sex and then normalized. Regression tree analyses were performed to identify the impact of geneti

SUBMITTER: Mezzavilla M 

PROVIDER: S-EPMC5791363 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature