Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs).

ABSTRACT: BACKGROUND:Transfection of NF κB synthetic decoy Oligodeoxynucleotides (ODNs) has been proposed as a promising therapeutic strategy for a variety of diseases arising from constitutive activation of the eukaryotic transcription factor NF κB. The decoy approach faces some limitations under physiological conditions notably nuclease-induced degradation. RESULTS:In this work, we show how a systems pharmacology model of NF κB regulatory networks displaying oscillatory temporal dynamics, can be used to predict quantitatively the dependence of therapeutic efficacy of NF κB synthetic decoy ODNs on dose, unbinding kinetic rates and nuclease-induced degradation rates. Both deterministic mass action simulations and stochastic simulations of the systems biology model show that the therapeutic efficacy

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5791368 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature