HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

ABSTRACT:

Background

Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We set out to understand the genomics of HER2 amplification independent of subtype, and the underlying drivers and biology of HER2E tumors.

Methods

We investigated published genomic data from 3155 breast tumors and 5391 non-breast tumors.

Results

HER2 amplification is a distinct driver event seen in all breast cancer subtypes, rather than a subtype marker, with major characteristics restricted to amplification and overexpression of HER2 and neighboring genes. The HER2E subtype has a distinctive transcriptional l

SUBMITTER: Daemen A 

PROVIDER: S-EPMC5791377 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature