A Merged Aldol Condensation, Alkene Isomerization, Cycloaddition/Cycloreversion Sequence Employing Oxazinone Intermediates for the Synthesis of Substituted Pyridines.

ABSTRACT: A domino reaction sequence has been evaluated that begins with union of novel dihydrooxazinone precursors with 2-alkynyl-substituted benzaldehyde components through aldol condensation. Ensuing operations, including alkene isomerization, Diels-Alder, and retrograde Diels-Alder with loss of CO₂ occurs in the same reaction vessel to provide polysubstituted tricyclic pyridine products.

SUBMITTER: Williamson JB 

PROVIDER: S-EPMC5791744 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature