Linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer.

ABSTRACT: LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα^- tumors correlated with negative overall survival, w

SUBMITTER: Abdul-Rahman U 

PROVIDER: S-EPMC5791815 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature