Ontology highlight
ABSTRACT:
SUBMITTER: Posavec Marjanovic M
PROVIDER: S-EPMC5791885 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20171009 11
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD<sup>+</sup>-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding ma ...[more]