Association of Fibrosing Myopathy in Systemic Sclerosis and Higher Mortality.

ABSTRACT:

Objective

To determine if a unique subtype of scleroderma muscle disease exists by comparing the clinical features of systemic sclerosis (SSc; scleroderma) patients with predominant fibrosis on muscle biopsy to those with inflammatory muscle histopathology.

Methods

This retrospective, cross-sectional study included SSc patients with muscle weakness and an available muscle biopsy. Biopsies with fibrosis but without inflammation/necrosis were designated as "fibrosing myopathy," and those with inflammation and/or necrosis were assigned a category of "inflammatory myopathy." Clinical data, including features of SSc, serum creatine kinase (CK) levels, electromyography, autoantibody profile, and survival, were compared between the 2 groups.

Results

The study population cons

SUBMITTER: Paik JJ 

PROVIDER: S-EPMC5791890 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature