Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.

ABSTRACT: A common occurrence in metazoan development is the rise of multiple tissues/organs from a single uniform precursor field. One example is the anterior forebrain of vertebrates, which produces the eyes, hypothalamus, diencephalon, and telencephalon. Another instance is the Drosophila wing disc, which generates the adult wing blade, the hinge, and the thorax. Gene regulatory networks (GRNs) that are comprised of signaling pathways and batteries of transcription factors parcel the undifferentiated field into discrete territories. This simple model is challenged by two observations. First, many GRN members that are thought to control the fate of one organ are actually expressed throughout the entire precursor field at earlier points in development. Second, each GRN can simultaneously promote on

SUBMITTER: Palliyil S 

PROVIDER: S-EPMC5792024 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature