A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.

ABSTRACT: Targeting key regulators of the cancer stem cell phenotype to overcome their critical influence on tumor growth is a promising new strategy for cancer treatment. Here we present a modeling framework that operates at both the cellular and molecular levels, for investigating IL-6 mediated, cancer stem cell driven tumor growth and targeted treatment with anti-IL6 antibodies. Our immediate goal is to quantify the influence of IL-6 on cancer stem cell self-renewal and survival, and to characterize the subsequent impact on tumor growth dynamics. By including the molecular details of IL-6 binding, we are able to quantify the temporal changes in fractional occupancies of bound receptors and their influence on tumor volume. There is a strong correlation between the model output and experimental dat

SUBMITTER: Nazari F 

PROVIDER: S-EPMC5792033 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature