Excitable Signal Transduction Networks in Directed Cell Migration.

ABSTRACT: Although directed migration of eukaryotic cells may have evolved to escape nutrient depletion, it has been adopted for an extensive range of physiological events during development and in the adult organism. The subversion of these movements results in disease, such as cancer. Mechanisms of propulsion and sensing are extremely diverse, but most eukaryotic cells move by extending actin-filled protrusions termed macropinosomes, pseudopodia, or lamellipodia or by extension of blebs. In addition to motility, directed migration involves polarity and directional sensing. The hundreds of gene products involved in these processes are organized into networks of parallel and interconnected pathways. Many of these components are activated or inhibited coordinately with stimulation and on each spontan

SUBMITTER: Devreotes PN 

PROVIDER: S-EPMC5792054 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature