The role of radical radiotherapy in the management of malignant pleural mesothelioma: A systematic review.

ABSTRACT: Malignant pleural mesothelioma (MPM) is a devastating disease with limited treatment options and a dismal prognosis. Attempts to employ radical radiotherapy in this disease have been limited by the complex shape of the pleura and the dose restrictions necessitated by the close proximity of radiosensitive structures. Recent shifts towards a 'lung sparing' surgical approach in MPM have further heightened these challenges. The aim of this systematic review is to assess recent advances in radiotherapy planning and delivery, to ascertain how these developments have impacted on the feasibility of delivering photon-based, high-dose radiotherapy with radical intent in MPM. Three electronic databases were searched and a total of 249 articles reviewed. The challenge of generating high quality, pract

SUBMITTER: Ashton M 

PROVIDER: S-EPMC5792070 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature