Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung.

ABSTRACT:

Background

Homeostatic turnover of the extracellular matrix conditions the structure and function of the healthy lung. In lung transplantation, long-term management remains limited by chronic lung allograft dysfunction, an umbrella term used for a heterogeneous entity ultimately associated with pathological airway and/or parenchyma remodeling.

Objective

This study assessed whether the local cross-talk between the pulmonary microbiota and host cells is a key determinant in the control of lower airway remodeling posttransplantation.

Methods

Microbiota DNA and host total RNA were isolated from 189 bronchoalveolar lavages obtained from 116 patients post lung transplantation. Expression of a set of 11 genes encoding either matrix components or factors involved in matrix sy

SUBMITTER: Mouraux S 

PROVIDER: S-EPMC5792246 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature