Ontology highlight
ABSTRACT:
SUBMITTER: DeVos SL
PROVIDER: S-EPMC5792300 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Science translational medicine 20170101 374
Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to reduce total tau expression. We identified antisense oligonucleotides (ASOs) that selectively decreased human tau mRNA and protein in mice expressing mutant P301S human tau. After reduction of human tau in this mouse model of tauopathy, fewer tau inclusions developed, and preexisting phosphorylated tau and Thioflavin S patholo ...[more]