Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress.

ABSTRACT: Although autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of multiple kidney cysts, the most frequent cause of death in ADPKD patients is cardiovascular disease. ADPKD is linked to mutations in PKD1 or pkd2, the genes that encode for the proteins polycystin 1 and polycystin 2 (PC1 and PC2, respectively). The cardiovascular complications have been assumed to be a consequence of renal hypertension and activation of renin/angiotensin/aldosterone (RAAS) pathway. However, the expression of PC1 and PC2 in cardiac tissue suggests additional direct effects of these proteins on cardiac function. We previously reported that zebrafish lacking PC2 develop heart failure, and that heterozygous Pkd2^+/- mice are hypersensitive to acute β-adrenergic recept

SUBMITTER: Giehl E 

PROVIDER: S-EPMC5792378 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature