Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses.

ABSTRACT: Avian influenza virus is a zoonotic agent that significantly impacts public health and the poultry industry. Monitoring viral evolution and spread is crucial for surveillance and tracing programmes, which are currently based on serological or DNA sequencing-phylogenetics analysis. However, virus-host interactions, antigenic drift and spreading of viral clades strongly depend on variation in the surface features of capsid proteins. We report here that in silico comparative structural analysis of haemagglutinin can reveal relevant evolutionary fingerprints, particularly when integrated with sequence-based analyses. Phylogenetic analyses of H9 viral strains from wild birds and poultry, performed with different methods, reliably led to clustering of viruses into five main groups. Subsequent co

SUBMITTER: Heidari A 

PROVIDER: S-EPMC5792503 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature