Identification of differential protein-coding gene expressions in early phase lung adenocarcinoma.

ABSTRACT:

Background

The diagnosis of early phase lung adenocarcinoma (LADC) is associated with therapeutic strategy, effect, and survival time. However, the sensitive biomarkers of early phase LADC are still unclear. This study aimed to identify protein-coding genes that can be used as biomarkers of early stage LADC.

Methods

Gene microarray analysis was performed to identify key hub genes that show different expression in lung adenocarcinoma compared to normal tissues. The microarray data of lung adenocarcinoma in stages IA, IB, IIA, IIB, and normal tissues (GSE10072) were downloaded from a free online database, Gene Expression Omnibus (GEO).

Results

A total of 572 differentially expressed genes (DEGs) were identified between early phase lung adenocarcinoma and normal tissues

SUBMITTER: Zhou LN 

PROVIDER: S-EPMC5792719 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature