Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.

ABSTRACT: Metastasis is the leading cause of death in patients with advanced melanoma, yet the somatic alterations that aid tumour cell dissemination and colonisation are poorly understood. Here, we deploy comparative genomics to identify and validate clinically relevant drivers of melanoma metastasis. To do this, we identified a set of 976 genes whose expression level was associated with a poor outcome in patients from two large melanoma cohorts. Next, we characterised the genomes and transcriptomes of mouse melanoma cell lines defined as weakly metastatic, and their highly metastatic derivatives. By comparing expression data between species, we identified lunatic fringe (LFNG), among 28 genes whose expression level is predictive of poor prognosis and whose altered expression is associated with a p

SUBMITTER: Del Castillo Velasco-Herrera M 

PROVIDER: S-EPMC5792739 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature