Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents.

ABSTRACT: Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of the particles (size, shape, surface charge, ionic content) with their specific activity. In this paper, we propose an effective multi-step approach for the identification of a 'purpose-specific active applicability window' to maximize the antimicrobial activity of medical devices containing silver nanoparticles (Ag NPs) (such as surface coaters), minimizing any consequent risk for human health (safety by design strategy). The antimicrobial activity and the cellular toxicity of four types of Ag NPs, differing in their coating composition and concentration have been quantified

SUBMITTER: Marassi V 

PROVIDER: S-EPMC5792903 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature