Topical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Mice.

ABSTRACT: Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a glycolipid fraction (MGDG) obtained from the microalga Isochrysis galbana on a TPA-induced epidermal hyperplasia murine model. In a first set of experiments, we examined the preventive effects of MGMG-A and MGDG dissolved in acetone on TPA-induced hyperplasia model in mice. In a second step, we performed an in vivo permeability study by using rhodamine-containing cream

SUBMITTER: Rodriguez-Luna A 

PROVIDER: S-EPMC5793050 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature