Transcription Factor and lncRNA Regulatory Networks Identify Key Elements in Lung Adenocarcinoma.

ABSTRACT: Lung cancer is the second most commonly diagnosed carcinoma and is the leading cause of cancer death. Although significant progress has been made towards its understanding and treatment, unraveling the complexities of lung cancer is still hampered by a lack of comprehensive knowledge on the mechanisms underlying the disease. High-throughput and multidimensional genomic data have shed new light on cancer biology. In this study, we developed a network-based approach integrating somatic mutations, the transcriptome, DNA methylation, and protein-DNA interactions to reveal the key regulators in lung adenocarcinoma (LUAD). By combining Bayesian network analysis with tissue-specific transcription factor (TF) and targeted gene interactions, we inferred 15 disease-related core regulatory networks i

SUBMITTER: Li D 

PROVIDER: S-EPMC5793165 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature