Identification of Transposable Elements Contributing to Tissue-Specific Expression of Long Non-Coding RNAs.

ABSTRACT: It has been recently suggested that transposable elements (TEs) are re-used as functional elements of long non-coding RNAs (lncRNAs). This is supported by some examples such as the human endogenous retrovirus subfamily H (HERVH) elements contained within lncRNAs and expressed specifically in human embryonic stem cells (hESCs), as required to maintain hESC identity. There are at least two unanswered questions about all lncRNAs. How many TEs are re-used within lncRNAs? Are there any other TEs that affect tissue specificity of lncRNA expression? To answer these questions, we comprehensively identify TEs that are significantly related to tissue-specific expression levels of lncRNAs. We downloaded lncRNA expression data corresponding to normal human tissue from the Expression Atlas and transfor

SUBMITTER: Chishima T 

PROVIDER: S-EPMC5793176 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature