Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

ABSTRACT: Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association. For proof of concept, we derived Y-DNA haplogroups from 6537 m

SUBMITTER: Erzurumluoglu AM 

PROVIDER: S-EPMC5793196 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature