Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy.

ABSTRACT: The molecular mechanisms underlying the development of ischemic cardiomyopathy (ICM) remain poorly understood. Gene expression profiling is helpful to discover the molecular changes taking place in ICM. The aim of this study was to identify the genes that are significantly changed during the development of heart failure caused by ICM. The differentially expressed genes (DEGs) were identified from 162 control samples and 227 ICM patients. PANTHER was used to perform gene ontology (GO), and Reactome for pathway enrichment analysis. A protein-protein interaction network was established using STRING and Cytoscape. A further validation was performed by real-time polymerase chain reaction (RT-PCR). A total of 255 common DEGs was found. Gene ontology, pathway enrichment, and protein-protein inter

SUBMITTER: Li Y 

PROVIDER: S-EPMC5793207 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature