Transition Metal Doping Reveals Link between Electron T₁ Reduction and ¹³C Dynamic Nuclear Polarization Efficiency.

ABSTRACT: Optimal efficiency of dissolution dynamic nuclear polarization (DNP) is essential to provide the required high sensitivity enhancements for in vitro and in vivo hyperpolarized ¹³C nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI). At the nexus of the DNP process are the free electrons, which provide the high spin alignment that is transferred to the nuclear spins. Without changing DNP instrumental conditions, one way to improve ¹³C DNP efficiency is by adding trace amounts of paramagnetic additives such as lanthanide (e.g., Gd³⁺, Ho³⁺, Dy³⁺, Tb³⁺) complexes to the DNP sample, which has been observed to increase solid-state ¹³C DNP signals by 100-250%. Herein, we have investigated the effects of param

SUBMITTER: Niedbalski P 

PROVIDER: S-EPMC5793213 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature