Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.

ABSTRACT:

Background

Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions and macromolecules through the pore and leak pathways, respectively, thereby preventing the absorption of harmful compounds and microbes while allowing regulated transport of nutrients and electrolytes. Small intestinal epithelial permeability is ascribed primarily to the properties of TJs between adjoining enterocytes (ENTs), because there is almost no information on TJ composition and the paracellular permeability of nonenterocyte cell types that constitute a small but significant fraction of the intestinal epithelia.

Results

Here we directed murine intestinal crypts to form specialized organoids hi

SUBMITTER: Pearce SC 

PROVIDER: S-EPMC5793346 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature