Breed-dependent microRNA expression in the primary culture of skeletal muscle cells subjected to myogenic differentiation.

ABSTRACT:

Background

Skeletal muscle in livestock develops into meat, an important source of protein and other nutrients for human consumption. The muscle is largely composed of a fixed number of multinucleated myofibers determined during late gestation and remains constant postnatally. A population of postnatal muscle stem cells, called satellite cells, gives rise to myoblast cells that can fuse with the existing myofibers, thus increasing their size. This requires a delicate balance of transcription and growth factors and specific microRNA (miRNA) expressed by satellite cells and their supporting cells from the muscle stem cell niche. The role of transcription and growth factors in bovine myogenesis is well-characterized; however, very little is known about the miRNA activity during this p

SUBMITTER: Sadkowski T 

PROVIDER: S-EPMC5793348 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature