Evolutionary fates of universal stress protein paralogs in Platyhelminthes.

ABSTRACT:

Background

Universal stress proteins (USPs) are present in all domains of life. Their expression is upregulated in response to a large variety of stress conditions. The functional diversity found in this protein family, paired with the sequence degeneration of the characteristic ATP-binding motif, suggests a complex evolutionary pattern for the paralogous USP-encoding genes. In this work, we investigated the origin, genomic organization, expression patterns and evolutionary history of the USP gene family in species of the phylum Platyhelminthes.

Results

Our data showed a cluster organization, a lineage-specific distribution, and the presence of several pseudogenes among the USP gene copies identified. The absence of a well conserved -CCAATCA- motif in the promoter region was

SUBMITTER: Espinola SM 

PROVIDER: S-EPMC5793430 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature