Equine glucagon-like peptide-1 receptor physiology.

ABSTRACT:

Background

Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin response to carbohydrate intake in animals with EMS. However, little is known about the equine GLP-1 receptor (eGLP-1R), or whether GLP-1 concentrations can be manipulated. The objectives were to determine (1) the tissue localisation of the eGLP-1R, (2) the GLP-1 secretory capacity of equine intestine in response to glucose and (3) whether GLP-1 stimulated insulin secretion from isolated pancreatic islets can be attenuated.

Methods

Archived and abattoir-sourced tissues from healthy horses were used. Reverse transcript

SUBMITTER: Kheder MH 

PROVIDER: S-EPMC5793710 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature