Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs.

ABSTRACT: Temporal control of physiology requires the interplay between gene networks involved in daily timekeeping and tissue function across different organs. How the circadian clock interweaves with tissue-specific transcriptional programs is poorly understood. Here, we dissected temporal and tissue-specific regulation at multiple gene regulatory layers by examining mouse tissues with an intact or disrupted clock over time. Integrated analysis uncovered two distinct regulatory modes underlying tissue-specific rhythms: tissue-specific oscillations in transcription factor (TF) activity, which were linked to feeding-fasting cycles in liver and sodium homeostasis in kidney; and colocalized binding of clock and tissue-specific transcription factors at distal enhancers. Chromosome conformation capture

SUBMITTER: Yeung J 

PROVIDER: S-EPMC5793782 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature