HDOCK: a web server for protein-protein and protein-DNA/RNA docking based on a hybrid strategy.

ABSTRACT: Protein-protein and protein-DNA/RNA interactions play a fundamental role in a variety of biological processes. Determining the complex structures of these interactions is valuable, in which molecular docking has played an important role. To automatically make use of the binding information from the PDB in docking, here we have presented HDOCK, a novel web server of our hybrid docking algorithm of template-based modeling and free docking, in which cases with misleading templates can be rescued by the free docking protocol. The server supports protein-protein and protein-DNA/RNA docking and accepts both sequence and structure inputs for proteins. The docking process is fast and consumes about 10-20 min for a docking run. Tested on the cases with weakly homologous complexes of <30% sequence i

SUBMITTER: Yan Y 

PROVIDER: S-EPMC5793843 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature