Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.

ABSTRACT: The developmental fate of hematopoietic stem and progenitor cells is influenced by their physiological context. Although most hematopoietic stem and progenitor cells are found in the bone marrow of the adult, some are found in other tissues, including the spleen. The extent to which the fate of stem cells is determined by the tissue in which they reside is not clear. In this study, we identify a new progenitor population, which is enriched in the mouse spleen, defined by cKit⁺CD71^lowCD24^high expression. This previously uncharacterized population generates exclusively myeloid lineage cells, including erythrocytes, platelets, monocytes, and neutrophils. These multipotent progenitors of the spleen (MPPS) develop from MPP2, a myeloid-biased subset of hematopoie

SUBMITTER: Mumau MD 

PROVIDER: S-EPMC5793861 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature