ROBUST MIXED EFFECTS MODEL FOR CLUSTERED FAILURE TIME DATA: APPLICATION TO HUNTINGTON'S DISEASE EVENT MEASURES.

ABSTRACT: An important goal in clinical and statistical research is properly modeling the distribution for clustered failure times which have a natural intraclass dependency and are subject to censoring. We handle these challenges with a novel approach that does not impose restrictive modeling or distributional assumptions. Using a logit transformation, we relate the distribution for clustered failure times to covariates and a random, subject-specific effect. The covariates are modeled with unknown functional forms, and the random effect may depend on the covariates and have an unknown and unspecified distribution. We introduce pseudovalues to handle censoring and splines for functional covariate effects, and frame the problem into fitting an additive logistic mixed effects model. Unlike existing ap

SUBMITTER: Garcia TP 

PROVIDER: S-EPMC5793916 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature