A prospective evaluation of the established criteria for heart failure with preserved ejection fraction using the Alberta HEART cohort.

ABSTRACT:

Aims

Heart failure with a preserved ejection fraction (HF-PEF) remains a difficult clinical diagnosis. The aim of this study was to test the utility of established criteria to classify patients with HF-PEF. We prospectively enrolled patients into one of five groups across a spectrum of cardiac disease and applied three different criteria for HF-PEF and calculated diagnostic metrics.

Methods and results

A total of 565 patients were included in the analysis, including 170 patients with an adjudicated diagnosis of HF-PEF, 152 patients with heart failure with reduced ejection fraction, 152 patients at risk for heart failure, and 91 age-matched healthy controls. For the diagnosis of HF-PEF, the positive likelihood ratios were 6.1, 6.9, and 4.8 for the Zile, European Society of Ca

SUBMITTER: Ezekowitz JA 

PROVIDER: S-EPMC5793977 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature