Testosterone vs. aromatase inhibitor in older men with low testosterone: effects on cardiometabolic parameters.

ABSTRACT: Testosterone (T) replacement is being increasingly offered to older men with age-related decline in testosterone levels. The effects of long-term testosterone replacement and aromatase inhibition (AI) on glucose homeostasis and cardiometabolic markers were determine in older non-diabetic men with low testosterone levels. Men ≥65 years, mean age 71 ± 3 years with serum total T < 350 ng/dL were randomized in a double-blind, placebo-controlled, parallel-group, proof-of-concept trial evaluating the effects of 5 g transdermal testosterone gel (TT) (n = 10), 1 mg anastrozole (n = 10) or placebo (n = 9) daily for 12 months. Homeostatic Model Assessment of insulin resistance (HOMA_IR ) was the primary outcome. Secondary outcomes included OGIS in response to OGTT, fasting lipids, C-reacti

SUBMITTER: Dias JP 

PROVIDER: S-EPMC5794008 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature