Osteoblast-derived factors induce an expression signature that identifies prostate cancer metastasis and hormonal progression.

ABSTRACT: Identification of gene expression signatures associated with metastases provides a tool to discern mechanisms and potential therapeutic targets and may lead toward a molecular classification system in pathology. Prostate cancer (CaP) frequently metastasizes to the bone to form osteoblastic lesions. Correlative clinical data and in vitro evidence have led to the hypothesis that osteoblast-derived factors promote hormonal progression of CaP cells. Here, the gene expression signature of CaP exposed to osteoblast-derived factors was identified. This signature included known androgen-regulated genes, oncogenes, tumor suppressors, and genes whose products are involved in apoptosis and cell cycle. A comparative functional genomic approach involved the application of this responsive gene expressio

SUBMITTER: Wang G 

PROVIDER: S-EPMC5794011 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature