Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis.

ABSTRACT:

Scope

Conjugated linoleic acids are linoleic acid isomers found in the diet that can also be produced through bacterial metabolism of polyunsaturated fatty acids. Our objective was to evaluate the contribution of fatty acid metabolites produced from polyunsaturated fatty acids by the gut microbiota in vivo to regulation of hepatic lipid metabolism and steatosis.

Methods and results

In mice with depleted n-3 polyunsaturated fatty acids, we observed an accumulation of trans-11,trans-13 CLA and cis-9,cis-11 conjugated linoleic acids in the liver tissue that were associated with an increased triglyceride content and expression of lipogenic genes. We used an in vitro model to evaluate the impact of these two conjugated linoleic acids on hepatic lipid metabolism. In HepG2 cells, w

SUBMITTER: Pachikian BD 

PROVIDER: S-EPMC5794163 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature