Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

ABSTRACT: Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to control the disease. Sirtuins, also called Silent information regulator 2 (Sir2) proteins have long been suggested as interesting targets to treat different diseases, including parasitic infections. Recent studies on Trypanosoma cruzi sirtuins have hinted at the possibility to exploit these enzymes as a possible drug targets. In the present work, the T. cruzi Sir2 related protein 1 (TcSir2rp1) is genetica

SUBMITTER: Gaspar L 

PROVIDER: S-EPMC5794198 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature