Distinct patterns of reduced prefrontal and limbic grey matter volume in childhood general and internalizing psychopathology.

ABSTRACT: Reduced grey matter volume (GMV) is widely implicated in psychopathology, but studies have found mostly overlapping areas of GMV reduction across disorders rather than unique neural signatures, potentially due to pervasive comorbidity. GMV reductions may be associated with broader psychopathology dimensions rather than specific disorders. We used an empirically supported bifactor model consisting of common psychopathology and internalizing- and externalizing-specific factors to evaluate whether latent psychopathology dimensions yield a clearer, more parsimonious pattern of GMV reduction in prefrontal and limbic/paralimbic areas implicated in individual disorders. A community sample of children (n=254, ages 6-10) was used to to evaluate whether GMV reductions could constitute early n

SUBMITTER: Snyder HR 

PROVIDER: S-EPMC5794221 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature