The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: The cardiovascular health study.

ABSTRACT: 25-hydroxyvitamin D [25(OH)D] may not optimally indicate vitamin D receptor activity. Higher concentrations of its catabolic product 24,25-dihydroxyvitmin D [24,25(OH)₂D] and a higher ratio of 24,25(OH)₂D to 25(OH)D (the vitamin D metabolite ratio [VMR]) may provide additional information on receptor activity. We compared the strength of associations of these markers with serum PTH concentrations, hip bone mineral density (BMD), and risk of incident hip fracture in community-living older participants in the Cardiovascular Health Study. Among 890 participants, the mean age was 78years, 60% were women, and the mean 25(OH)D was 28±11ng/ml. In cross-sectional analysis, the strength of association of each vitamin D measure with PTH was similar; a 1% higher 25(OH)D, 24,25(O

SUBMITTER: Ginsberg C 

PROVIDER: S-EPMC5794222 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature