Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model.

ABSTRACT: Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. Through technological advances, the entire lipidome has been characterized and researchers now need computational approaches to better understand lipid network perturbations in different diseases. Using a mouse model of type 2 diabetes with microvascular complications, we examined lipid levels in plasma and in renal, neural, and retinal tissues to identify shared and distinct lipid abnormalities. We used correlation analysis to construct interaction networks in each tissue, to associate changes in lipids with changes in enzymes of lipid metabolism, and to identify overlap of coregulated lipid subclasses between

SUBMITTER: Sas KM 

PROVIDER: S-EPMC5794414 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature