MiR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression.

ABSTRACT: Fewer than 30% of patients with hepatocellular carcinoma (HCC) are eligible to receive curative therapies, and so a better understanding of the molecular mechanisms of HCC is needed to identify potential therapeutic targets. The role of microRNA (miRNA) in modulating tumour progression has been demonstrated, and therapies targeting miRNA appear promising. miR-204-5p has been shown to function in numerous types of cancer, but its role in HCC remains unclear. In this study, we found that miR-204-5p expression was downregulated in cancerous HCC tissues compared to nontumour tissues. Kaplan-Meier survival curve analysis also showed that low expression of miR-204-5p predicted worse outcomes of HCC patients. In addition, miR-204-5p expression was significantly lower in HCC cell lines. The functi

SUBMITTER: Chu Y 

PROVIDER: S-EPMC5794460 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature