Effects of Androgen Deprivation Therapy on Pain Perception, Quality of Life, and Depression in Men With Prostate Cancer.

ABSTRACT:

Context

Previous animal and human research suggests that testosterone has antinociceptive properties. Castration in male rodents increases pain perception which is reversed by testosterone replacement. Pain perception also improves in hypogonadal men with testosterone therapy. However, it remains unclear whether androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an increase in pain perception.

Objectives

To evaluate the effects of ADT on pain perception, depression and quality of life (QOL) in men with PCa.

Methods

Thirty-seven men with PCa about to undergo ADT with leuprolide acetate (ADT group) were followed prospectively for six months to evaluate changes in clinical and experimental pain. Forty men who had previously undergone

SUBMITTER: Gagliano-Juca T 

PROVIDER: S-EPMC5794536 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature