Postprandial High-Resolution Impedance Manometry Identifies Mechanisms of Nonresponse to Proton Pump Inhibitors.

ABSTRACT:

Background & aims

Recognition of rumination and supragastric belching is often delayed as symptoms may be mistakenly attributed to gastroesophageal reflux disease. However, distinct from gastroesophageal reflux disease, rumination and supragastric belching are more responsive to behavioral interventions than to acid-suppressive and antireflux therapies. Postprandial high-resolution impedance manometry (PP-HRIM) is an efficient method to identify rumination and belches. We investigated the distribution of postprandial profiles determined by PP-HRIM, and identified patient features associated with postprandial profiles among patients with nonresponse to proton pump inhibitors (PPIs).

Methods

We performed a retrospective analysis of PP-HRIM studies performed on 94 adults (mean

SUBMITTER: Yadlapati R 

PROVIDER: S-EPMC5794564 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature