Examination of the role of obesity in the association between childhood trauma and inflammation during pregnancy.

ABSTRACT:

Objective

Childhood trauma is associated with negative perinatal health outcomes including mood disorders and shorter gestation. However, effects of early life exposures on maternal biology are poorly delineated. This study examined associations between childhood trauma and inflammation, as well as the mediating role of obesity in this relationship.

Method

This study examined a racially diverse sample of 77 pregnant women assessed in early, mid, and late pregnancy. Assessments included the Childhood Trauma Questionnaire, Center for Epidemiologic Studies-Depression Scale, serum CRP, IL-6, and TNF-α, and prepregnancy BMI.

Results

Per linear mixed models, while no direct relationships were observed between childhood trauma with IL-6 or TNF-α, physical (95% CI: 0.007, 0.0

SUBMITTER: Mitchell AM 

PROVIDER: S-EPMC5794605 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature