Periconception Exposure to Air Pollution and Risk of Congenital Malformations.

ABSTRACT: OBJECTIVE:To evaluate the association between increased exposure to airborne fine particulate matter (PM2.5) during the periconception period with risk of congenital anomalies. STUDY DESIGN:Using birth certificate data from the Ohio Department of Health (2006-2010) and PM2.5 data from the US Environmental Protection Agency's 57 monitoring stations located throughout Ohio, the geographic coordinates of the mother's residence for each birth were linked to the nearest PM2.5 monitoring station and monthly exposure averages were calculated. The association between congenital anomalies and increased PM2.5 levels was estimated, with adjustment for coexistent risk factors. RESULTS:After adjustment for coexisting risk factors, exposure to increased levels of PM2.5 in the air during the periconcepti

SUBMITTER: Ren S 

PROVIDER: S-EPMC5794608 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature